What Happens?

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What Happens?

NEWTONSTEIN "MEDIPEDIA™"

Some Possible D.H.E.A. side effects?

DHEA: Side effects?

Review of safety and adverse eventsIndividuals with normal levels of this hormone in their bloodstream who take high doses are likely get DHEA side effects.

Common side effects caused by high doses include:

> Acne and pimples

Acne can occur due to increase levels of androgens. There are those who are very prone to acne eruptions and they could have pimples develop within a day or two. I know others who have taken this androgen hormone for months and years without any skin problems.

> Breast swelling

My friend is 42 and took DHEA 25mg for about 2 months. Her breasts have started to swell painfully. She already needs a bigger bra size.

> Cancer, tumor formation

High dosing for prolonged periods - many years - could theoretically increase the risk for certain cancers such as breast cancer and prostate cancer.

> It is well-known that excess exposure to many types of hormones, such as androgens, progesterone and estrogens, increases the risk for certain types of cancer.

Hair loss side effects, thinning hair is a concern in men and women

Any androgenic steroid, such as DHEA, testosterone and androstenedione can cause the side effect of hair loss or thinning in susceptible individuals.

DHEA is likely to raise levels of testosterone and dihydrotestosterone (DHT) in the hair follicles.

Too much DHT will lead to hair loss.

Taking DHEA when a person’s body does not need it will lead to excess DHT and cause hair loss in many people probably even in one’s 20s. Too many people are taking high dosages of these hormones on a regular basis without really needing them.

Anyone who wishes to regain their hair should discuss with their physician about stopping the hormones.

The temporary (2 to 3 month) use of finasteride [Propecia (1 mg) or Proscar (5 mg)] could stop the hair loss and possibly regrow part or all of the lost. It is difficult to predict how long a person would need to take finasteride.

Women may benefit from minoxidil 2% and could discuss with their physician about the use of a medicine called spironolactone.

Whether hair regrows on its own after stopping DHEA or whether a medications such as finasteride is necessary to help regrow is not clear at this time.

NEWTONSTEIN "MEDIPEDIA™"

D.H.E.A. Summary and bottom line, final review

DHEA is made from cholesterol and is a natural hormone that has been available over-the-counter since the mid 1990s.

No fatalities have been recorded in the medical literature regarding the use of this hormone by the general public.

There is little justification for DHEA supplementation in healthy elderly subjects, except perhaps in tiny doses of 1 or 2 mg, perhaps up to 5 mg in some people.

Thus far studies have failed to prove for beneficial effects of DHEA on muscle function, bone metabolism or cognition.

However, more research with DHEA may provide the answers we currently lack. There is a lot of information regarding hormone, nutrition, medicine, and health matters on the internet, and it is up to consumers to decide which website's information they trust.

It would certainly be safer if there were times when one stops taking these hormones. You could call this 'cycling'. There are many ways to do this.

You could take these hormones

>> every other day,

>> five days on, two days off,

>> take them for a week and off a week

>> or take them for three weeks and off a week.

The dosage needs to be individualized to each person's needs.

This is based on regular evaluations of a basic physical exam, including blood pressure, heart rate, examination of hair and skin, evaluation of routine blood studies, and monitoring of mood, sleep patterns, energy levels, and motivation.

Women need to have regular breast exams and Pap tests. Men need to have their prostate exam.

Although blood or saliva DHEA levels are important to monitor, in the end, the important point to keep in mind is what kind of influence DHEA or other hormones are having on our brain, organs and tissues.

It is possible, that taking too much of these hormones, too long, could actually shorten lifespan.

DHEA and pregnenolone are not like vitamin C.

More is not necessarily better.

There's a smaller range to play with. I get uncomfortable when I hear of doctors prescribing 25 or 50 mg a day to their patients.

NEWTONSTEIN "MEDIPEDIA™"

D.H.E.A. Review of research studies

In my opinion, based on its reported benefits, side effects, and safety profile, I believe it’s important that the public should continue to have access to it as a dietary supplement. However it is recommended that consumers discuss with their health care provider before undertaking any regular use of this hormone.

It is also recommended that the natural health industry itself put forward that dietary supplement companies voluntarily sell and recommend only low dosages of this hormone, such as 5 mg.

Since 5 mg pills of DHEA are difficult to find, those who plan to take this hormone under medical supervision could open a capsule of 25 mg and take only a small portion, or take a portion of a tablet.

Since DHEA can increase alertness, morning use is best; although each individual is unique and some prefer mid-day or even bedtime dosing. Bedtime dose should be very low in order not to disturb sleep.

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QUESTION: Is DHEA the only adrenal hormone?

More than 150 hormones are known to be synthesized by the adrenal glands.

However, the most abundant hormone made by the adrenal glands is DHEA. After DHEA is made by these glands it goes into the bloodstream, and from then on it travels all over the body and goes into our cells, where it is converted into male hormones, known as androgens, or female hormones, known as estrogens.

Whether DHEA gets converted predominantly into androgens or estrogens depends on a person's medical condition, age, genetics, and gender.

Every person has a unique biochemistry. In males the testicles also make androgens, while in females, before menopause, the ovaries also make estrogens. So the body has developed at least two organs where sex steroids are made. After menopause, the ovaries no longer make estrogens.

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Will natural yam extract pills increase my DHEA levels?

Most of the DHEA sold now in vitamin stores or through mail order firms is produced in a laboratory from diosgenin. However, some vitamin companies do sell extracts of wild yams in pill form, without first processing it into DHEA. Some even promote these yam-extract products as "DHEA precursor complexes."

DHEA is made commercially from a plant of the dioscorea family [wild yams] found in abundance in Mexico. Extracts of this plant contain a steroidal saponin called diosgenin which may be converted in a laboratory by a series of 6 to 8 chemical reactions into DHEA.

A comparable series of reactions is not known to exist in nature and certainly not in humans. Consequently it is highly unlikely, perhaps impossible is a better word, that the ingestion of extracts of the dioscorea plant will lead to the formation, by metabolic transformation of the relevant plant constituent, to either pregnenolone or DHEA.

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Cause of high DHEA levels

Very high levels may be caused by Cushing's disease or syndrome, an overproduction in the adrenal glands or the ovaries.Women with PCOS could have high levels.

However, most of the time, an isolated high level on a blood or saliva test may not be significant and it is worthwhile to have the levels tested in a few weeks since levels fluctuate and a one time reading of a high DHEA may not mean anything.

Also, it is important, before any therapy is initiated, to have a repeat test by another laboratory since the measurement of this hormone can vary between different labs.

Body hair growth, acne, menstrual changes, etc., are some of the consequences of excess DHEA. If a person has a high level but no other symptoms, I do not seen any reason to treat. I prefer treating the whole person, not an isolated blood study result.

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What supplements are available to reduce those natural DHEA levels?

I recommend a medical evaluation to find out why this is happening, sometimes a tumor or cysts can be the cause of this excessive production. Steps can be taken to resolve this problem if the source of the overproduction is found. I'm not aware of any natural supplements that lower levels.

Perhaps weight loss can decrease the levels of this hormone in some individuals.

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Use with natural supplements at the same time

I live in Italy and my doctor prescribed me 20 mg alternated 3 days a week with pregnenolone 25 mg. I'm 41 yers old. My doctor suggest me to take some anti-aromatase supplement like chrysin. But I read that chrysin is a fake promise: it has no anti-aromatase effect.

So suggest to my doctor that I can take DIM (with Bioperine). He said ok. I am not sure and before to begin a hormonal therapy I'd like to the right thing: which anti-aromatase can I take? Please give me the right advise. I'm your fan.

SPEAKS TO CHRYSIN and DIM:

I am not aware of any research that indicate the use of chrysin or DIM supplements can counter some of the side effects of these hormones. I think your doctor may benefit from reading the cautions that I discuss regarding the use and dosage of these hormones.

NEWTONSTEIN "MEDIPEDIA™"

D.H.E.A. Some Emails received: review

My husband has just had some saliva tests done which showed his DHEA level to be very high (88ng/ml compared with a norm for his age (53) of 3-10). He is not taking a DHEA supplement. He has many of the symptoms of high DHEA - acne, palpitations etc. Are there any known risks with a high natural level?

First, I am not convinced saliva tests for DHEA are completely accurate since different labs may have different ways of doing them, and I suspect saliva levels may not reflect accurately levels in various cells in the body where it really counts. Second, there are other causes for acne and heart rhythm irregularities, not just DHEA.

If it is true that someone has high levels of androgens, it is possible that over time this could increase the risk for androgen sensitive tumors such as prostate cancer or other problems like hair loss or enlarged prostate.

Before accepting these high levels to be true, it would be best to have the DHEA level tested by another health care provider at another lab, and this time by blood. And then repeat the blood study a couple of more times over a period of several weeks or months.

Congrats that you are spreading the word not to take more than 5 mg DHEA daily. I cringe when I see/hear people taking 50-100mg and even more per day . Here's the kick. Even at 5 mg DHEA, it can trigger a very aggressive / explosive feeling in me that I don't like.

Verbal, not physical. I lose my temper very easy even on 5mg dhea. It's almost embarrassing to me going through this. Temper can be awful. Every time I come off it, that temper subsides within 2-3 days, completely gone within a week. I think everyone should be aware of this.

DHEA can ruin lives if people do not understand it. There is alot of good with DHEA, but there are drawbacks, some major, as stated above. Two other potential drawbacks for me (and others). DHEA actually seems to be addicting. I have now started / stopped DHEA for 8 periods (being on for a few weeks each time).

Each time I start out swearing I'll only take 5mg every other day and by the end of the month, I'll be taking 5-10mg each day, one time even going up to 30mg a day. I also have a hard time stopping it even knowing it's building up and my moods are going haywire.

I've often read about the mood elevation of DHEA. BUT, I notice it's not steady (for me). I can go up and down, sometimes way down, quite often when taking this hormone supplement. Again, I've read this from others also. I think we need to be fair/realistic when touting any med or supplement. Bottom line: There can be major drawbacks / side effects when taking even small doses of DHEA

NEWTONSTEIN "MEDIPEDIA™"

Some Possible D.H.E.A. side effects? Questions;

Q. I have taken two separate saliva tests to check my DHEA level -- both before and after starting daily supplementation -- and found it to be low both times. The two different labs I used both advise to collect the saliva samples in the morning prior to the next usage.

The normal ranges of DHEA levels for different age groups on the back of the test results reflect levels found 8-12 hours after last usage. However, based on your DHEA book and other sources, I take my DHEA supplement in the morning.

Should DHEA supplements be taken at night if one is to take a morning saliva test, and, if so, how long does one need to supplement at night prior to taking a morning saliva test in order to get an accurate reading. Thank you. P.S. I just bought a copy of Mind Boosters and am finding it most informative and well written.

A. The whole issue of DHEA testing, accuracy of lab results, interpretation of results, and clinical significance of these results is still a murky issue with no definitive guidelines or medical consensus.

Blood or saliva levels don't completely tell us what's going on inside cells and how much of these hormones are in the cells and tissues of hair, skin, brain, liver, other organs, etc. Since there are a number of unanswered questions medicine still has to resolve, the best approach is to take low doses of DHEA (if you plan to take it at all) and not put an overemphasis on saliva or blood testing.

It's quite likely that if you take a DHEA pill in the morning, unless it is a very high dose, it would be practically out of your system by next morning when you are having your saliva test. If you take the DHEA the night before, even a few hours difference on the timing could make a difference in your saliva levels. Basically, for the time being, blood or saliva levels of DHEA are a way to know if you are deficient, and help give a clue as to whether or not to take the hormone.

You may also wish to reevaluate why you are taking DHEA in the first place. Are there other non-hormone supplements that could help you achieve your desired goals (energy, mood, sex drive, vitality, memory, etc.) and would have fewer side effects? Perhaps you could take some of these supplements and thus lower your dose of DHEA.

In chapter 2 of Mind Boosters (an engine alone does not run a car) I mention that it is better to use a few different supplements together in small dosages as opposed to one or two in higher amounts.

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I took 25 mg of dhea for 3 weeks. I found myself getting irritable and had fluttering in the chest. I stopped taking the hormone supplement, and within a week to a week and a half, i began alot of strange symptoms: anxiousness, perspiration, clamminess about the neck, and extremities, panic attacks, tingling out the head and both arms.

I have been off dhea supplements for two weeks now. What is the half-life of supplementation once halted, and are there any known side-effects associated with cessation of the hormone?

The half life of DHEA is less than a day. DHEA likely caused the irritability and fluttering of the chest, but I'm not eager to blame the DHEA for your symptoms that started a week later. I do recommend a medical evaluation to rule out a cardiac or other condition that accounted for your symptoms.

My recommendation for DHEA dosage on a regular basis is 5 mg or less. I believe 25 mg of DHEA is a high dose. I am often criticized by some individuals in the vitamin industry for my low dosage recommendations for hormones and supplements, and your case of fluttering in the chest (which I have come across often) confirms my position on keeping my dosage recommendations for DHEA on the low side.

I’m told by one of my patients that they currently take a daily amount of a product by the name of Super Plus which, they claim, is an amalgamation of various herbs and natural ingredients which supposedly stimulate the body’s production of its own natural DHEA. Have you heard of this product and if so, what is your evaluation of it and its efficacy as a precursor for natural DHEA enhancement?

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According to a website selling Super Plus, the promoters claim it stimulates the adrenal cortex to increase DHEA production. They also claim, "In addition to the Wild Yam, (150 mgs of 4-1 extract) equating to 600 mgs, the makers of Super-Plus incorporated many other nutritional ingredients to assist in the boosting of natural Progesterone, DHEA, cleansing the cells, and strengthening the immune system.

Extensive research and care in the formulation, quality control and manufacturing process make Super-Plus the finest, safest, most effective product on the market for better health." Whenever you see a product being promoted with these kinds of adjectives: finest, safest, most effective product on the market,"

you can immediately be quite suspicious that the company making this product lacks integrity. Have they tested their product against tens of thousands of other products on the market to determine that it is the "finest, safest.... etc"? Of course not. When I see this kind of promotion, I no longer feel the need to learn more about this product since I lose trust in the company. There is no evidence that wild yam converts into DHEA in the human body.

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I am a 40 yo female; extremely healthy all my life. My mother experienced menopause at 40, shortly after having me. Now it seems it is my turn! Life seemed to suddenly come to a screeching halt for me. Never being sick in my life, I knew something must be awry with my hormones.

I am currently undergoing (very recently started) bio-identical hormone pellet therapy from a M.D. team and I am satisfied so far because a complete blood work up revealed my levels were all in the lower 1-5% of the desired 'bell curve'.

I've felt the first relief in nearly two years. Anyway, my doctors have also suggested I take their DHEA and pregnenolone for certain reasons. I know the DHEA causes me to feel anxious to outright aggressive and mean; in even doses as low a 5mg.

I've asked to avoid taking it, but they strongly encouraged me to at least take the pregnenolone to help keep my very low progesterone levels elevated as well as for brain-support and breast-cancer preventative measures.

Dosage 25 mg /day 3 x week. I am also on oral progesterone up to 200 mg/day (normally 100 mg) as well as the creams from Life-Flo. So, I came home to research more thoroughly. Earlier I had read your website about the cautions regarding dosage, and when I learned pregnenolone can also convert into DHEA, I immediately did not want to take it.

There are many web sites on the internet that tout the benefits of the hormones DHEA and pregnenolone while minimizing their side effects. Their are doctors who prescribe high dosages of these hormones without realizing the risks they pose. I have a different viewpoint. These hormones are powerful and they can cause serious side effects as listed at the top of the page. You may ask your doctors to read about the dangers on this web site.

NEWTONSTEIN "MEDIPEDIA™"

D.H.E.A. References:

Hackbert L, Heiman JR. Acute dehydroepiandrosterone (DHEA) effects on sexual arousal in postmenopausal women. J Womens Health Gend Based Med. 2002 Mar;11(2):155-62.

Hirshman E, et al. The effect of dehydroepiandrosterone (DHEA) on recognition memory decision processes and discrimination in postmenopausal women. Psychon Bull Rev. 2003 Mar;10(1):125-34.

Johannsson G, et al. Low dose DHEA affects behavior in hypopituitary androgen-deficient women: a placebo-controlled trial. J Clin Endocrinol Metab. 2002 May;87(5):2046-52.Lovas K, et al. Replacement of DHEA in adrenal failure: no benefit for subjective health status and sexuality in a 9-month, randomized, parallel group clinical trial. J Clin Endocrinol Metab. 2003 Mar;88(3):1112-8.

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