Intermittent Fasting - The Bible Way!
The practice of the people of God was to fast two days a week for life!
Fasting is better than simple calorie reduction that allows regular ingestion of small amounts of food.
Fasting, among other benefits, allows for the body to produce more youth-growth hormone any time humans go at least five hours without any food intake!
Fasting does this grandly!
The 1945 study by Carlson and Hoelzel, referenced above, found that the apparent life span of rats in the study was increased by intermittent fasting. Tests in which a group of thirty-three rats were allowed the same food ad libitum and groups of thirty-seven, thirty-seven and thirty rats were fasted 1 day in 4, 3 and 2, respectively, after the age of 42 days, showed that the optimum amount of fasting appeared to be fasting 1 day in 3 and this increased the life span of littermate males about 20% and littermate females about 15%.
This is the amount the Bible teaches!
Studies by Mark P. Mattson, Ph. D., chief of the National Institute on Aging's (NIA) Laboratory of Neurosciences, and colleagues have found that intermittent fasting and calorie restriction affect the progression of diseases similar to Huntington's disease, Parkinson's disease, and Alzheimer's disease in mice (PMID 11119686).
In one study, rats and mice ate a low-calorie diet or were deprived of food for 24 hours every other day. [The Bible Way!]
Both methods improved glucose metabolism, increased insulin sensitivity, and increased stress resistance.
Researchers have long been aware that calorie restriction extends lifespan, but this study showed that improved glucose metabolism also protects neurons in experimental models of Parkinson's and stroke.
The brains of the fasting mice also showed less degeneration.
Those on the fasting program also regulated their glucose levels better and did not lose weight as quickly as the other mice. Researchers found that fasting mice had higher brain-derived neurotrophic factor (BDNF) levels. BDNF protects neurons and stimulates their growth. Fasting mice also had high levels of heat-shock protein-70 (Hsp70), which increases cellular resistance to stress.
Another NIA study compared intermittent fasting with cutting calorie intake. Researchers let a control group of mice eat freely (ad libitum). Another group was fed 60% of the calories that the control group consumed. A third group was fasted for 24 hours, then permitted to free-feed. The fasting mice didn't cut total calories at the beginning and the end of the observation period, and only slightly cut calories in between. A fourth group was fed the average daily intake of the fasting mice every day. Both the fasting mice and those on a restricted diet had significantly lower blood sugar and insulin levels than the free-fed controls. Kainic acid, a toxin that damages neurons, was injected into the dorsal hippocampus of all mice. Hippocampal damage is associated with Alzheimer's. Interestingly, the scientists found less damage in the brains of the fasting mice than in those that ate a restricted diet, and most damage in mice with an unrestricted diet. But the control group which ate the average daily intake of the fasting mice also showed less damage than the mice with restricted diet.
Another Mattson study in which overweight adult asthmatics followed alternate day calorie restriction (ADCR) for eight weeks showed marked improvement in oxidative stress, inflammation, and severity of the disease. Evidence from the medical literature suggests that ADCR in the absence of weight loss prolongs lifespan in humans.
Intermittent fasting has also been shown to increase the resistance of neurons in the brain to excitotoxic stress.
A number of subsequent studies have shown beneficial effects of IF in animals.
"Reduced serum glucose and insulin levels and increased resistance of neurons in the brain to excitotoxic stress" "Enhance[s] cardiovascular and brain functions and improve[s] several risk factors for coronary artery disease and stroke including a reduction in blood pressure and increased insulin sensitivity" and that "cardiovascular stress adaptation is improved and heart rate variability is increased in rodents" and that "rodents maintained on an IF regimen exhibit increased resistance of heart and brain cells to ischemic injury in experimental models of myocardial infarction and stroke." May "ameliorate age-related deficits in cognitive function" in mice Correlation with IF and significantly improved biochemical parameters associated with development of diabetic nephropathy Resistance in mice to the effects of gamma irradiation Lifespan increases of 40.4% and 56.6% in C. elegans for alternate day (24 hour) and two-of-each-three day (48 hour) fasting, respectively, as compared to an ad libitum diet. Rats showed markedly improved long-term survival after chronic heart failure via pro-angiogenic, anti-apoptotic and anti-remodeling effects.
 Human Studies
Similarly, recent studies on humans suggest similar beneficial results.
Alternative day fasting (ADF) may produce significant improvements in several markers such as LDL cholesterol in as little as eight weeks. ADF "may effectively modulate several risk factors, thereby preventing chronic disease, and that ADF may modulate disease risk to an extent similar to that of CR". Serum from humans following an IF diet had positive effects (reduced triglycerides in men and increased HDL in women, as well as reduced cell proliferation and increased heat resistance) in vitro on human hepatoma cells. IF confers protection from toxic chemotherapy treatments, allowing higher doses and therefore more effective treatment for cancers. IF may function as a form of nutritional hormesis.
 As a human diet
A number of individuals are experimenting with different varieties of IF as a dietary regime. In this context, shorthand such as "20/4" is used to denote a repeating pattern of 20 hours of fasting followed by 4 hours of non-fasting. ("Fast-5" is the name of a book/regime equivalent to "19/5".)
The phase of the fasting period may also be specified. Practitioners often start the fasting period at the commencement of nightly sleep.
Unlike the use of IF in scientific experiments, in popular usage the term is sometimes also applied even when the fasting period involves consumption of some calorie-containing beverages.
Another variation on IF is to consume limited calories (e.g., 20% of normal) rather than none at all on fasting days. This regimen may provide many of the benefits of IF.
Research also exists on increased meal frequency, but there is little evidence that it offers a benefit over IF regimens or conventional 3 meal diets.
A critique/review of a research review by the International Society of Sports Nutrition references further peer reviewed articles to cast doubt on the few (and weak) positive benefits of high meal frequency diets finding that increasing meal frequency "does not appear to favorably change body composition in sedentary populations", "does not appear to significantly enhance diet induced thermogenesis, total energy expenditure or resting metabolic rate",
but may "have a positive effect on various blood markers of health, particularly LDL cholesterol, total cholesterol, and insulin" (however this data is limited and seems to conflict with other human and animal research ),
and in addition high frequency meals did have some research support that it could be beneficial for satiety and preserving lean body mass in athletic individuals on low energy diets, however, evidence for the benefits of high meal frequency diets is discussed to be limited and questionable or conflicting. 
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