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http://www.foothill.edu/printmaking/MSDS/Windex_MSDS.pdf The first topical skin cancer treatment that I found works quite well is Cymilium, an over the counter insect bite remedy. Cymilium is a beige cream that comes in a carton containing 14 little foil pouches. Each little pouch is said to contain 2 doses, but I found I could get around 15 applications out of each one. I simply applied the Cymilium several times a day with my finger to my lesion with skin cancer symptoms, briefly working it into the skin until it disappeared. I then rinsed my finger because it became a little irritated over time if I did not rinse it. I usually reapplied it whenever I had to use the restroom. There was a bit of a sting and smell from the ammonia that went away within a minute. Otherwise the treatment was painless for me. For the first few days my lesion seemed to swell somewhat. After that, the lesion became well defined and then started to shrink in size. Significant healing progress of my probable skin cancer lesion was observed within a week. Cymilium is listed for purchase for about $10 US at www.cymilium.com in April 2004. I did not hyperlink this intentionally. I am not promoting, nor do I want to appear like I am promoting this product. This product is apparently not otherwise widely available. The good news regarding Cymilium is that the components of an effective topical treatment for skin cancer, at least in my experience, are known. The ingredients disclosed on the Cymilium box are the active ingredient ammonium hydroxide 3% in a base containing aloe vera, cetyl alcohol, diazolidinyl urea, emulsifying wax, methylparaben, mineral oil, pancreatin, petrolatum, polyethylene glycol distearate, propylene glycol, propylparaben, sodium laurel ether sulfate, stearic acid, urea, and water. Ammonium hydroxide is commonly known as ammonia. Petrolatum is commonly known as Vaseline or petroleum jelly. I think the most critical ingredients in the Cymilium product for topical skin cancer treatment are pancreatin, ammonia, aloe vera, urea, and possibly stearic acid. The other ingredients in the Cymilium preparation probably function as preservatives and topical carriers that disperse the active ingredients, maintain contact with the skin, and prevent rapid evaporation. The urea compounds in particular may also act as wetting agents and penetration enhancers. Urea works by breaking up the surface tension of the fluid that surrounds the cancer cells, allowing access of the other ingredients to the cancer cell membranes. Many of these ingredients, except for pancreatin and ammonia, can be found in common skin lotions. Intended for insect bite relief, it has also been found to be useful in some cases to treat non-melanoma skin cancers according to testimonial reports. Here is some rationale for picking pancreatin, ammonia, aloe vera as the most important ingredients of Cymilium. I think the pancreatin enzymes kill the cancer cells by breaking up the proteins in the cell membranes, possibly allowing the cell to be recognized as defective or foreign by other body defenses. Aloe vera contains polysaccharides which stimulate immune defenses. Aloe vera also contains amylase enzymes that break up carbohydrate based strands that can block the access of the pancreatin enzymes to the membranes of the cancer cells. Aloe vera is easily absorbed into the skin and acts as a carrier for the pancreatin. Aloe vera gel may help with detoxification of the dead cancer cells. The ammonia makes the mixture alkaline to protect the pancreatin from acids that tend to destroy it. Ammonia probably has other functions as well. The degree of acidity and alkalinity of a substance is characterized using a pH (potential Hydrogen) scale that ranges from 0 to 14. A pH of 7 is in the middle of the scale and is considered neutral. An acid has a pH below 7 and is stronger as the number approaches 0. An alkaline has a pH above 7 and is stronger as the number approaches 14. Both strongly acidic (pH typically less than 2.5) and strongly alkaline (pH typically greater than 11.5) substances can cause burn-like injuries to skin. Each change in the pH scale by one is a factor of ten different in concentration. Cancer cells are sensitive to both alkaline and acid environments. Cancer cells in the laboratory grow most rapidly at a pH of about 5.5 and quickly die when exposed to a pH of 8.5 or greater. Cancer cells also die in the laboratory when exposed to acids with a pH less than 2.5. The problem with using acids to attack skin cancer is that normal skin will experience acid burns near that pH level. Attacking cancer from the alkaline side makes more sense in terms of safety and being able to utilize other immune defenses. Ammonium hydroxide (ammonia diluted in water) makes the environment very hostile to the cancer. The ammonia helps get the mixture through the acid mantle (dead outer layer) of the skin and also neutralizes the acid envelope that surrounds the cancer tumor. Ammonia has the fastest rate of skin penetration of common alkalies. Ammonia exposure leaves the tissues alkaline for several hours. These are potentially desirable qualities for topical skin cancer treatments. Pancreatin enzymes, and especially the protein dissolving enzyme trypsin, are most effective in an alkaline environment with a pH of 8.5 but still work less optimally over a pH range of about 6.5 to 9.5. Skin cancer lesions are normally more acidic than normal skin. This is because their metabolism of glucose is anaerobic so that they generate substantial lactic acid byproducts, and their internal blood circulation is poor. The pH of an ideal topical solution would appear to be in the range of 9.0 to 11.0 to be relatively safe for skin contact, be capable of neutralizing the acid environment surrounding the lesion, enable the direct killing of cancer cells by making their environment alkaline, and promote the optimal activity of pancreatin enzymes. Household ammonia typically has a pH of about 11.5. Other familiar pH reference points are baking soda with a pH of 8.5, Ivory brand bar soap with a pH of 9.5, milk of magnesia with a pH of 10.5, and Windex (as in the movie My Big Fat Greek Wedding) with a pH of 12. Stearic acid could also play a role in Cymilium. Stearic acid is a saturated fat molecule that has an exceptionally strong affinity for free ionic calcium Ca2+. Consumed by the cancer cell, the excess Ca2+ attracted by the stearic acid is speculated to cause the cancer cell's glucose metabolism to shut down, and the cancer cell soon dies. In order for this scenario to work, sufficient calcium must also be available in the blood. Other experimental cancer drugs target the Ca2+ cancer cell apoptosis (cell death) mechanism. This speculation may or may not be correct, but eating an alkalizing diet with adequate calcium is a good idea in any case. TO FOOTNOTE [1] [1] (The footnote goes here)  *COPYRIGHT NOTICE** In accordance with Title 17 U.S.C. Section 107, any copyrighted work in the NewtonStein, Cambridge Theological Seminary is archived here under fair use without profit or payment to those who have expressed a prior interest in reviewing the included information for personal use, non-profit research, and educational purposes only. Ref. http://www.law.cornell.edu/uscode/17/107.shtml
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